Autophagosome membrane docking

Across TCGA cell cohorts, RNA activity of the Autophagosome membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP8, SPINT1, and RHOD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome membrane docking activity versus VAMP8 in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VAMP8 →	+2.202	+0.192	.009	.002	3	7
OVARY	SPINT1 →	+3.402	+0.434	.002	.008	3	6
LUNG_NSCLC_LUAD	RHOD →	+1.762	+0.365	.001	.007	3	6
URINARY_TRACT	SYTL1 →	+3.692	+0.298	.004	.003	3	5
LUNG_NSCLC_LUAD	CAPN1 →	+0.941	+0.413	.003	.002	3	5
LUNG_NSCLC_LUAD	FAM171A1 →	-1.984	-0.298	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016240 vs VAMP8 — BREAST

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