Positive regulation of macroautophagy

Across TCGA patient cohorts, RNA activity of the Positive regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, PIF1, and CPSF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macroautophagy activity versus GINS1 in LSCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GINS1 →	-0.575	-0.132	.007	<.001	3	5
BRCA	PIF1 →	-0.718	-0.146	.002	<.001	3	5
BRCA	CPSF3 →	-0.344	-0.138	.001	.001	3	4
BRCA	E2F3 →	-0.717	-0.181	<.001	<.001	3	4
UCEC	CIT →	-0.468	-0.145	<.001	.002	3	4
LSCC	GTPBP3 →	-0.453	-0.130	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016239 vs GINS1 — LSCC

Explore this scatter interactively →