Positive regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of macroautophagy pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GARS1, EFCAB8, and NTHL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GARS1 grouped by Positive regulation of macroautophagy-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GARS1 →	+0.329	+0.234	.003	.005	3	5
LARGE_INTESTINE	EFCAB8 →	-0.690	-0.140	<.001	.001	3	4
BREAST	NTHL1 →	-0.201	-0.155	<.001	.007	3	4
PANCREAS	RAP2B →	-0.186	-0.182	<.001	.001	3	4
SOFT_TISSUE	CHRM4 →	-0.152	-0.175	.003	.006	3	3
LUNG_SCLC	FBRSL1 →	-0.223	-0.159	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GARS1 by Positive regulation of macroautophagy activity — BLOOD_Leukemia

Explore this box plot interactively →