Microautophagy

Across TCGA patient cohorts, RNA activity of the Microautophagy pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP123, ZNF814, and ZNF671, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microautophagy activity versus RNA5SP123 in PDAC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RNA5SP123 →	-0.494	-0.652	<.001	.006	3	4
GBM	ZNF814 →	-0.528	-0.232	<.001	<.001	3	4
GBM	ZNF671 →	-0.612	-0.304	<.001	<.001	3	4
COAD	TRIM29 →	+0.784	+0.294	.009	.009	3	3
LUAD	SLC25A36P1 →	-0.319	-0.640	.005	.001	3	3
GBM	MRPS31 →	-0.246	-0.329	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016237 vs RNA5SP123 — PDAC

Explore this scatter interactively →