Microautophagy

Across TCGA cell cohorts, RNA activity of the Microautophagy pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLUL, CPSF7, and DMKN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLUL grouped by Microautophagy-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GLUL →	+2.276	+0.874	<.001	.001	3	3
LARGE_INTESTINE	CPSF7 →	+0.564	+0.614	.004	.004	3	3
LARGE_INTESTINE	DMKN →	+2.367	+0.462	.001	.002	3	3
OESOPHAGUS	ATP6V0A2 →	+0.951	+0.296	.001	.004	3	3
BONE	ACYP1 →	+1.130	+0.995	.006	.007	3	3
BLOOD_Lymphoma	PIDD1 →	+0.812	+0.539	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLUL by Microautophagy activity — LARGE_INTESTINE

Explore this box plot interactively →