Microautophagy

Across TCGA cell cohorts, RNA activity of the Microautophagy pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS4A, CENPT, and BCL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microautophagy activity versus VPS4A in BONE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	VPS4A →	+0.698	+1.440	.007	.005	3	6
SKIN	CENPT →	+0.832	+0.773	<.001	.003	3	5
LARGE_INTESTINE	BCL2 →	+0.865	+0.749	<.001	.002	3	5
BREAST	KIAA0895L →	+0.921	+0.925	.003	.007	3	5
BONE	TIRAP →	+0.539	+1.876	.001	<.001	3	4
BONE	GABARAPL2 →	+0.618	+1.466	.001	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016237 vs VPS4A — BONE

Explore this scatter interactively →