Telomere capping

Across TCGA patient cohorts, RNA activity of the Telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, MTRNR2L3, and SEH1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere capping activity versus HELLS in HNSC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HELLS →	+0.541	+0.204	.004	<.001	3	4
HNSC	MTRNR2L3 →	+0.577	+0.210	.001	<.001	3	4
LSCC	SEH1L →	+0.662	+0.220	<.001	<.001	3	4
GBM	GINS1 →	+0.681	+0.259	.001	.008	3	4
LSCC	DKC1 →	+0.507	+0.165	<.001	.001	3	4
GBM	MKI67 →	+0.816	+0.179	.004	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016233 vs HELLS — HNSC

Explore this scatter interactively →