Telomere capping

Across TCGA cell cohorts, RNA activity of the Telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRE11, NOC3L, and CTC1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere capping activity versus MRE11 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRE11 →	+1.049	+0.073	<.001	.001	3	13
BLOOD_Lymphoma	NOC3L →	+1.002	+0.086	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	CTC1 →	+1.305	+0.124	<.001	<.001	3	12
OVARY	ZFP1 →	+0.940	+0.089	<.001	<.001	3	12
LIVER	SFR1 →	+1.310	+0.090	<.001	.002	3	12
OVARY	PMS1 →	+0.981	+0.086	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016233 vs MRE11 — UPPER_AERODIGESTIVE_TRACT

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