Telomere capping

Across TCGA cell cohorts, RNA activity of the Telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MND1, CD63, and MSH6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere capping activity versus MND1 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MND1 →	+0.726	+0.159	.003	.001	3	4
BLOOD_Leukemia	CD63 →	-0.879	-0.138	.003	.003	3	4
BLOOD_Lymphoma	MSH6 →	+1.826	+0.235	<.001	<.001	3	4
BLOOD_Lymphoma	TP53RK →	+0.493	+0.190	.008	<.001	3	4
PANCREAS	ECM1 →	-1.482	-0.226	.001	<.001	3	4
CNS	TUFT1 →	-0.999	-0.383	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016233 vs MND1 — BLOOD_Leukemia

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