Axon midline choice point recognition

Across TCGA patient cohorts, RNA activity of the Axon midline choice point recognition pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPK3, ROBO1_S940, and EPB41L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon midline choice point recognition activity versus MAPK3 in CCRCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MAPK3 →	-0.263	-0.105	<.001	<.001	3	6
HNSC	ROBO1_S940 →	+0.849	+0.161	<.001	<.001	3	5
HNSC	EPB41L1 →	-0.606	-0.137	<.001	<.001	3	5
CCRCC	CAVIN1 →	-0.375	-0.092	<.001	<.001	3	5
CCRCC	PPM1F →	-0.340	-0.095	<.001	<.001	3	5
CCRCC	RPL21 →	+0.198	+0.061	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016199 vs MAPK3 — CCRCC

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