Axon midline choice point recognition

Across TCGA patient cohorts, RNA activity of the Axon midline choice point recognition pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FIBIN, PSMB8-AS1, and RARRES2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon midline choice point recognition activity versus FIBIN in PDAC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FIBIN →	+0.587	+0.459	.003	.006	3	4
LUAD	PSMB8-AS1 →	-0.336	-0.399	.002	.008	3	3
PDAC	RARRES2 →	+0.398	+0.426	.002	.001	3	3
BRCA	PODNL1 →	+0.750	+0.386	<.001	.004	3	3
HNSC	MMP2 →	+0.770	+0.364	.003	.001	3	3
GBM	LINC01186 →	-0.111	-0.948	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016199 vs FIBIN — PDAC

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