Axon midline choice point recognition

Across TCGA cell cohorts, RNA activity of the Axon midline choice point recognition pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APP, ROBO1, and FOXG1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APP grouped by Axon midline choice point recognition-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	APP →	-0.374	-1.388	.006	.001	3	12
BREAST	ROBO1 →	-0.213	-1.162	<.001	<.001	3	6
BLOOD_Leukemia	FOXG1 →	-0.218	-1.234	<.001	.007	2	6
BREAST	PAK4 →	+0.132	+0.761	.004	.001	3	4
BREAST	BLOC1S2 →	-0.201	-0.733	.002	.002	3	4
BREAST	GNPTG →	+0.150	+1.007	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APP by Axon midline choice point recognition activity — OVARY

Explore this box plot interactively →