Axon midline choice point recognition

Across TCGA cell cohorts, RNA activity of the Axon midline choice point recognition pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC2, POLR2K, and HIGD1B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMC2 grouped by Axon midline choice point recognition-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EMC2 →	-1.480	-2.226	.008	<.001	2	3
KIDNEY	POLR2K →	-1.536	-2.226	.006	<.001	3	2
CNS	HIGD1B →	+0.267	+1.525	.007	.002	3	2
CNS	P2RY4 →	-0.190	-1.525	.004	.002	3	2
OESOPHAGUS	KRT6C →	-1.180	-1.499	.002	<.001	3	2
OESOPHAGUS	ZNF792 →	+0.971	+1.342	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMC2 by Axon midline choice point recognition activity — KIDNEY

Explore this box plot interactively →