Axon choice point recognition

Across TCGA patient cohorts, RNA activity of the Axon choice point recognition pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROBO1, LY86, and C1orf162, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon choice point recognition activity versus ROBO1 in LIHC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	ROBO1 →	+1.300	+0.092	<.001	<.001	3	19
SCLC	LY86 →	-1.088	-0.343	<.001	.007	2	19
LAML	C1orf162 →	-1.021	-0.203	<.001	<.001	2	19
TGCT	CD37 →	-1.285	-0.073	<.001	<.001	3	17
THYM	SASH3 →	-1.367	-0.058	<.001	<.001	3	17
THYM	GMFG →	-1.599	-0.066	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016198 vs ROBO1 — LIHC

Explore this scatter interactively →