Axon choice point recognition

Across TCGA patient cohorts, RNA activity of the Axon choice point recognition pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN2, LUM, and RPL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon choice point recognition activity versus CAVIN2 in COAD (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CAVIN2 →	-0.615	-0.058	.002	<.001	3	6
CCRCC	LUM →	-0.583	-0.058	<.001	.001	3	6
BRCA	RPL4 →	+0.294	+0.055	.008	.004	3	5
LSCC	RPL6 →	+0.366	+0.101	.001	<.001	3	5
GBM	CAV1 →	-0.740	-0.073	.001	.007	2	6
BRCA	CAV1_S37 →	-0.818	-0.058	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016198 vs CAVIN2 — COAD

Explore this scatter interactively →