Axon choice point recognition

Across TCGA patient cohorts, RNA activity of the Axon choice point recognition pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL4, ZNF778, and GRP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon choice point recognition activity versus CCL4 in OV (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCL4 →	-0.689	-0.509	.002	.007	3	4
GBM	ZNF778 →	+0.388	+0.224	<.001	.006	3	3
HNSC	GRP →	+0.705	+0.417	.001	.006	3	3
PDAC	RABIF →	-0.281	-0.552	.002	.006	3	3
LUAD	PSMB8 →	-0.437	-0.345	.004	.006	3	3
PDAC	NPM1P30 →	-0.368	-0.501	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016198 vs CCL4 — OV

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