Axon choice point recognition

Across TCGA cell cohorts, RNA activity of the Axon choice point recognition pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM6, ZC3HAV1L, and FBXO36, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDM6 grouped by Axon choice point recognition-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRDM6 →	-0.773	-1.228	.002	.009	3	3
LUNG_NSCLC_LUAD	ZC3HAV1L →	-0.764	-1.303	.002	<.001	3	3
LUNG_NSCLC_LUAD	FBXO36 →	-0.634	-0.875	.003	.005	3	3
LUNG_NSCLC_LUAD	DPY19L4 →	-0.477	-0.690	.006	.006	2	4
LUNG_NSCLC_LUAD	KRIT1 →	-0.576	-1.050	.001	.001	3	3
LUNG_NSCLC_LUAD	TYW1 →	-0.427	-0.670	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDM6 by Axon choice point recognition activity — OVARY

Explore this box plot interactively →