Axon choice point recognition

Across TCGA cell cohorts, RNA activity of the Axon choice point recognition pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2J2, MTMR4, and RBP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon choice point recognition activity versus CYP2J2 in CNS (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CYP2J2 →	-2.046	-1.708	.001	<.001	3	3
LUNG_SCLC	MTMR4 →	-0.845	-1.458	.006	.002	3	2
LUNG_SCLC	RBP1 →	-3.444	-1.561	.002	<.001	3	2
LUNG_SCLC	KLF12 →	-1.495	-1.491	.005	.002	3	2
LUNG_SCLC	VPS36 →	-0.775	-1.802	.006	<.001	3	2
LUNG_SCLC	TPMT →	+0.972	+1.330	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016198 vs CYP2J2 — CNS

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