Endosomal transport

Across TCGA patient cohorts, RNA activity of the Endosomal transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SERBP1, and RPS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosomal transport activity versus RPL5 in GBM (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.239	-0.045	<.001	<.001	3	7
OV	SERBP1 →	-0.307	-0.039	.006	.007	2	7
LUAD	RPS2 →	-0.208	-0.032	.001	<.001	3	6
OV	RTN1 →	+0.480	+0.034	.003	.007	3	6
LUAD	RPL6 →	-0.327	-0.024	.001	<.001	3	6
BRCA	RPL7L1 →	-0.307	-0.018	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016197 vs RPL5 — GBM

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