Endosomal transport

Across TCGA cell cohorts, RNA activity of the Endosomal transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANTXR1, ERP27, and C6orf132, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANTXR1 grouped by Endosomal transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ANTXR1 →	-2.323	-0.203	<.001	<.001	3	5
LUNG_NSCLC_LUAD	ERP27 →	+1.503	+0.268	.005	.007	3	5
BREAST	C6orf132 →	+1.513	+0.125	.004	.007	3	5
OESOPHAGUS	TMEM265 →	+2.574	+0.172	.006	.003	3	4
LUNG_NSCLC_LUSC	WDR83OS →	-0.925	-0.219	.005	.001	3	4
LUNG_NSCLC_LUSC	USP43 →	+1.243	+0.153	.006	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANTXR1 by Endosomal transport activity — OESOPHAGUS

Explore this box plot interactively →