Endosomal transport

Across TCGA cell cohorts, RNA activity of the Endosomal transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPGS2, SP2, and IDH3G, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosomal transport activity versus TPGS2 in BLOOD_Lymphoma (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TPGS2 →	+0.782	+0.072	.003	.004	2	6
SOFT_TISSUE	SP2 →	+0.528	+0.146	.005	.002	3	4
CNS	IDH3G →	+0.686	+0.136	.001	.001	3	4
BREAST	PSMC1 →	+0.610	+0.098	.002	.002	3	4
BREAST	SEC13 →	+0.769	+0.138	<.001	<.001	3	4
STOMACH	PIP4P1 →	+0.775	+0.167	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016197 vs TPGS2 — BLOOD_Lymphoma

Explore this scatter interactively →