Synaptic vesicle uncoating

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle uncoating pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNJ1, REPS2_T479, and THG1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle uncoating activity versus SYNJ1 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNJ1 →	+0.557	+0.144	<.001	<.001	3	6
GBM	REPS2_T479 →	+0.530	+0.089	<.001	<.001	3	5
BRCA	THG1L →	-0.163	-0.060	.009	.001	3	5
GBM	FAM107B →	+0.496	+0.073	<.001	.002	3	5
OV	RAB24 →	+0.477	+0.058	.002	.002	3	5
GBM	ARFGEF2_S218 →	+0.364	+0.076	.006	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016191 vs SYNJ1 — GBM

Explore this scatter interactively →