Synaptic vesicle uncoating

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle uncoating pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMI1, NIBAN1, and RPL35A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle uncoating activity versus RMI1 in OV (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RMI1 →	+0.648	+0.669	.003	.003	3	4
OV	NIBAN1 →	+0.947	+0.803	<.001	<.001	3	4
OV	RPL35A →	-0.687	-0.704	.002	<.001	3	3
BRCA	RNF7 →	-0.396	-0.686	.001	.009	3	3
LUAD	GAL3ST1 →	-0.599	-0.632	<.001	<.001	3	3
BRCA	TULP4 →	+0.513	+0.790	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016191 vs RMI1 — OV

Explore this scatter interactively →