Synaptic vesicle maturation

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ROGDI, SLC27A4, and VPS50, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle maturation activity versus ROGDI in GBM (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ROGDI →	+0.472	+0.114	<.001	<.001	3	6
PDAC	SLC27A4 →	+0.306	+0.040	.003	.002	2	6
GBM	VPS50 →	+0.219	+0.085	<.001	<.001	3	5
BRCA	IDI1 →	+0.442	+0.032	<.001	.001	3	5
OV	BANF1 →	-0.269	-0.033	.007	.006	2	6
GBM	RAB34 →	-0.425	-0.059	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016188 vs ROGDI — GBM

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