Synaptic vesicle maturation

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle maturation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFDC3, GSE1, and IFIT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WFDC3 grouped by Synaptic vesicle maturation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	WFDC3 →	+1.605	+0.257	.001	.002	3	5
BLOOD_Leukemia	GSE1 →	-1.445	-0.326	.001	.003	3	5
OVARY	IFIT3 →	+1.593	+0.270	.001	.002	3	5
STOMACH	EPHA2 →	+0.739	+0.286	.001	<.001	3	4
STOMACH	SEC31B →	-0.998	-0.234	.001	<.001	3	4
LIVER	ALDH18A1 →	-1.016	-0.267	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WFDC3 by Synaptic vesicle maturation activity — OESOPHAGUS

Explore this box plot interactively →