Synaptic vesicle maturation

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle maturation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD7, VPS35L, and CXCL16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle maturation activity versus KCTD7 in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCTD7 →	+0.801	+0.296	.003	.003	3	4
BONE	VPS35L →	+0.921	+0.339	.001	.004	3	4
BONE	CXCL16 →	-1.932	-0.282	.007	.008	3	4
UPPER_AERODIGESTIVE_TRACT	GNPTG →	+0.948	+1.001	.004	.008	3	4
BLOOD_Leukemia	IMPACT →	+2.896	+0.418	<.001	.004	3	3
OESOPHAGUS	NDUFB2 →	+1.241	+0.295	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016188 vs KCTD7 — BLOOD_Lymphoma

Explore this scatter interactively →