snRNA processing

Across TCGA patient cohorts, RNA activity of the snRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTL6A, STT3B, and TMEM214, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA processing activity versus ACTL6A in COAD (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACTL6A →	+0.179	+0.033	<.001	<.001	3	5
PDAC	STT3B →	-0.419	-0.022	<.001	.003	3	5
CCRCC	TMEM214 →	-0.303	-0.023	.009	.004	3	5
GBM	MESD →	-0.291	-0.041	<.001	.002	3	5
GBM	PHF3_S1184 →	+0.388	+0.046	<.001	<.001	3	5
LSCC	OSBPL3_S304 →	-0.356	-0.035	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016180 vs ACTL6A — COAD

Explore this scatter interactively →