snRNA processing

Across TCGA patient cohorts, RNA activity of the snRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HASPIN, RRAS, and CKAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA processing activity versus HASPIN in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HASPIN →	+0.771	+0.251	<.001	<.001	3	6
OV	RRAS →	-0.463	-0.173	.001	.001	3	5
OV	CKAP2 →	+0.619	+0.202	.008	.005	3	5
OV	MXRA8 →	-1.141	-0.202	.001	.002	3	5
OV	FAM180A →	-0.625	-0.204	.001	<.001	3	5
LUAD	FGF1 →	-0.728	-0.210	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016180 vs HASPIN — GBM

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