snRNA processing

Across TCGA cell cohorts, RNA activity of the snRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERP2, AP1G2, and MFSD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERP2 grouped by snRNA processing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SERP2 →	+2.468	+0.244	<.001	.007	3	4
OESOPHAGUS	AP1G2 →	+1.066	+0.236	.002	.004	3	4
CNS	MFSD1 →	+0.763	+0.131	.002	.006	3	4
CNS	PLEKHN1 →	+0.805	+0.147	.001	.001	3	4
BREAST	MAFK →	+0.846	+0.195	.001	.004	3	4
BREAST	H2BC6 →	+0.624	+0.197	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERP2 by snRNA processing activity — LUNG_SCLC

Explore this box plot interactively →