Glycoside catabolic process

Across TCGA patient cohorts, RNA activity of the Glycoside catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, VPS37B, and MAP1B_S2100, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoside catabolic process activity versus CRTAP in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRTAP →	+0.405	+0.053	.007	.003	3	5
GBM	VPS37B →	-0.308	-0.063	.001	<.001	3	5
LSCC	MAP1B_S2100 →	+1.132	+0.061	.001	.003	3	5
COAD	GLA →	+0.564	+0.039	<.001	<.001	3	5
GBM	CTSS →	+0.557	+0.055	<.001	<.001	3	4
GBM	PSAP →	+0.422	+0.058	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016139 vs CRTAP — GBM

Explore this scatter interactively →