Glycoside catabolic process

Across TCGA cell cohorts, RNA activity of the Glycoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRI3BP, TGFBI, and PSEN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRI3BP grouped by Glycoside catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRI3BP →	+0.564	+0.438	.008	.006	3	4
BLOOD_Leukemia	TGFBI →	+2.445	+0.598	.007	.006	3	3
BREAST	PSEN2 →	+0.592	+0.375	.003	.006	2	4
BREAST	ANK2 →	-0.898	-0.503	.006	.008	3	3
BREAST	HPSE →	-1.261	-0.541	.001	.004	3	3
BREAST	GPR160 →	+2.120	+0.537	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRI3BP by Glycoside catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →