Glycoside catabolic process

Across TCGA cell cohorts, RNA activity of the Glycoside catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD8, UBE2G1, and RTP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABHD8 grouped by Glycoside catabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ABHD8 →	-0.150	-0.159	.001	.002	3	5
LARGE_INTESTINE	UBE2G1 →	+0.177	+0.126	<.001	<.001	3	5
PANCREAS	RTP1 →	-0.191	-0.118	.002	.004	3	4
PANCREAS	DDX39B →	+0.455	+0.132	.001	.007	3	4
OVARY	ZNF680 →	+0.209	+0.129	<.001	.003	3	4
BLOOD_Myeloma	PNPLA3 →	-0.243	-0.160	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABHD8 by Glycoside catabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →