Sterol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHCR24, HMGCS1, and SQLE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol biosynthetic process activity versus DHCR24 in HNSC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHCR24 →	+0.976	+0.219	<.001	<.001	3	5
LSCC	HMGCS1 →	+1.135	+0.205	<.001	<.001	3	5
LSCC	SQLE →	+0.998	+0.202	<.001	<.001	3	5
COAD	CARD8 →	-0.395	-0.188	.002	.001	3	5
HNSC	CYP51A1 →	+0.763	+0.254	<.001	<.001	3	5
LSCC	N4BP2L1 →	-0.531	-0.182	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016126 vs DHCR24 — HNSC

Explore this scatter interactively →