Sterol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSS, FBXL2, and IDI1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol biosynthetic process activity versus LSS in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LSS →	+1.508	+0.288	<.001	.002	3	8
BREAST	FBXL2 →	-1.150	-0.337	.001	<.001	3	6
STOMACH	IDI1 →	+1.138	+0.349	.005	<.001	3	6
BLOOD_Lymphoma	SQLE →	+1.678	+0.247	.009	.001	3	5
PANCREAS	ACAT2 →	+0.980	+0.249	.009	.006	2	6
SKIN	HMGCS1 →	+1.860	+0.410	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016126 vs LSS — BLOOD_Lymphoma

Explore this scatter interactively →