Terpenoid catabolic process

Across TCGA patient cohorts, RNA activity of the Terpenoid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, AKR1B10, and CBR1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid catabolic process activity versus AKR1C3 in LSCC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+2.080	+0.239	<.001	<.001	3	10
LSCC	AKR1B10 →	+2.588	+0.223	<.001	<.001	3	9
LSCC	CBR1 →	+0.812	+0.199	<.001	<.001	3	6
LSCC	CYP4F11 →	+1.582	+0.203	<.001	<.001	3	6
LSCC	G6PD →	+0.912	+0.215	<.001	<.001	3	6
LSCC	TALDO1 →	+0.538	+0.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016115 vs AKR1C3 — LSCC

Explore this scatter interactively →