Terpenoid catabolic process

Across TCGA patient cohorts, RNA activity of the Terpenoid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B10, AKR1C3, and RASSF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid catabolic process activity versus AKR1B10 in LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR1B10 →	+2.558	+0.471	<.001	<.001	3	6
LSCC	AKR1C3 →	+1.762	+0.615	<.001	<.001	3	5
BRCA	RASSF2 →	-0.390	-0.465	.007	.002	3	3
COAD	SLC41A3 →	-0.405	-0.480	.006	.001	3	3
BRCA	CYTIP →	-0.924	-0.721	<.001	<.001	3	3
BRCA	MOB3B →	-0.691	-0.635	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016115 vs AKR1B10 — LUAD

Explore this scatter interactively →