Terpenoid catabolic process

Across TCGA cell cohorts, RNA activity of the Terpenoid catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDHA5, TMED5, and KCNA5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCDHA5 grouped by Terpenoid catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PCDHA5 →	+0.260	+2.105	.003	.003	3	2
LUNG_NSCLC_LUAD	TMED5 →	-0.176	-0.779	.005	.001	3	1
LUNG_NSCLC_LUAD	KCNA5 →	+0.155	+1.206	.001	.006	3	1
LUNG_NSCLC_LUAD	MED9 →	+0.438	+1.206	<.001	.006	3	1
LARGE_INTESTINE	MED13 →	+0.320	+2.018	.001	<.001	3	1
LARGE_INTESTINE	DNMT3A →	+0.200	+1.882	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCDHA5 by Terpenoid catabolic process activity — BREAST

Explore this box plot interactively →