Terpenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Terpenoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHRS3, RDH10, and AKR1C3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid biosynthetic process activity versus DHRS3 in LUAD (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DHRS3 →	+0.676	+0.049	<.001	.002	3	7
OV	RDH10 →	+0.628	+0.043	<.001	<.001	3	6
LSCC	AKR1C3 →	+1.300	+0.057	.001	.007	3	6
UCEC	PDLIM1 →	+0.508	+0.096	<.001	<.001	3	6
COAD	ACTN4 →	+0.283	+0.053	.001	.002	3	5
UCEC	PRR15 →	+0.518	+0.087	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016114 vs DHRS3 — LUAD

Explore this scatter interactively →