Terpenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Terpenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB20, HMGCS1, and EGR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid biosynthetic process activity versus ZBTB20 in HNSC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZBTB20 →	-0.612	-0.249	.005	<.001	3	5
HNSC	HMGCS1 →	+0.828	+0.290	<.001	<.001	3	4
LSCC	EGR2 →	-0.544	-0.191	.004	.002	3	4
LSCC	FDFT1 →	+0.431	+0.164	.002	<.001	3	4
HNSC	SPRR1B →	+1.762	+0.196	.004	.006	2	5
LSCC	SPRR1A →	+2.323	+0.198	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016114 vs ZBTB20 — HNSC

Explore this scatter interactively →