Terpenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Terpenoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FDFT1, HMGCS1, and HMGCS1_S495, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid biosynthetic process activity versus FDFT1 in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FDFT1 →	+0.659	+0.289	.001	<.001	3	5
LSCC	HMGCS1 →	+0.755	+0.293	<.001	<.001	3	4
LUAD	HMGCS1_S495 →	+1.360	+0.259	<.001	<.001	3	4
OV	SNX29_S810 →	-0.582	-0.266	<.001	<.001	3	3
COAD	SRRM2_S1982 →	-0.797	-0.298	<.001	<.001	3	3
OV	BOD1L1_S2501 →	-0.605	-0.215	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016114 vs FDFT1 — LSCC

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