Terpenoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Terpenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX22, EIF3F, and LRRC37A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX22 grouped by Terpenoid biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX22 →	-0.734	-1.075	.001	.002	3	4
PANCREAS	EIF3F →	-0.569	-0.496	<.001	.005	3	4
BLOOD_Leukemia	LRRC37A3 →	-0.820	-0.993	.003	.006	3	4
LARGE_INTESTINE	ZNF605 →	-1.155	-0.769	.002	.003	3	4
SOFT_TISSUE	DNAH10OS →	-0.496	-0.924	.005	.007	3	3
BONE	SLC22A17 →	-1.646	-0.355	.009	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX22 by Terpenoid biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →