Terpenoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Terpenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC6, SPACA6, and APOL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid biosynthetic process activity versus CDC6 in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CDC6 →	+0.721	+0.851	.003	.008	3	5
BLOOD_Myeloma	SPACA6 →	+1.192	+0.325	.005	.007	3	5
BLOOD_Lymphoma	APOL6 →	-2.469	-0.947	<.001	.003	3	5
OVARY	FGF1 →	-1.047	-0.763	.001	.001	3	4
LUNG_NSCLC_LUAD	CKS1B →	+0.614	+0.917	.002	<.001	3	4
LIVER	TOMM5 →	+1.380	+0.534	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016114 vs CDC6 — LUNG_NSCLC_LUAD

Explore this scatter interactively →