Diterpenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Diterpenoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RDH10, AKR1C3, and ALDH1A3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diterpenoid biosynthetic process activity versus RDH10 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RDH10 →	+0.716	+0.108	<.001	<.001	3	7
UCEC	AKR1C3 →	+1.124	+0.106	<.001	<.001	3	7
OV	ALDH1A3 →	+0.626	+0.046	.003	.002	3	7
BRCA	ZNF24 →	-0.435	-0.053	<.001	<.001	3	7
BRCA	CHAMP1 →	-0.254	-0.040	.001	.002	3	6
CCRCC	HMGB2 →	-0.257	-0.041	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016102 vs RDH10 — LSCC

Explore this scatter interactively →