Diterpenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Diterpenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS9, DHRS3, and BCAS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diterpenoid biosynthetic process activity versus DHRS9 in HNSC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHRS9 →	+1.373	+0.186	<.001	<.001	3	5
LSCC	DHRS3 →	+0.658	+0.196	.005	.003	2	6
LSCC	BCAS1 →	+1.110	+0.244	<.001	<.001	3	5
GBM	SMIM5 →	+0.299	+0.131	.008	.002	3	4
LUAD	HSD17B2 →	+0.735	+0.219	.002	<.001	2	5
UCEC	AGR2 →	+1.745	+0.143	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016102 vs DHRS9 — HNSC

Explore this scatter interactively →