Diterpenoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Diterpenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFS1, PEX6, and MIER3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WFS1 grouped by Diterpenoid biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WFS1 →	-1.431	-1.112	.006	.003	3	4
SKIN	PEX6 →	-0.689	-0.747	.002	.002	3	4
CNS	MIER3 →	-0.358	-0.926	.001	.001	3	3
CNS	RFC1 →	-0.555	-0.762	.002	.005	3	3
BREAST	TAF11 →	-0.535	-0.877	.009	.009	3	3
CNS	N4BP2 →	-0.609	-0.715	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WFS1 by Diterpenoid biosynthetic process activity — STOMACH

Explore this box plot interactively →