Diterpenoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Diterpenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPH5, RNF170, and CERS2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diterpenoid biosynthetic process activity versus DPH5 in OESOPHAGUS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DPH5 →	+0.608	+1.218	.002	.005	3	3
OESOPHAGUS	RNF170 →	+1.089	+1.183	.004	.007	3	3
OESOPHAGUS	CERS2 →	+0.928	+1.169	.001	.008	3	3
STOMACH	MSL2 →	+0.837	+0.432	.007	.004	3	3
OVARY	RFC1 →	+0.699	+1.486	.004	.005	3	3
URINARY_TRACT	WAC →	+0.724	+2.078	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016102 vs DPH5 — OESOPHAGUS

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