Monoterpenoid metabolic process

Across TCGA patient cohorts, RNA activity of the Monoterpenoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMSAP3, ITGA5, and C1QA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoterpenoid metabolic process activity versus CAMSAP3 in PDAC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CAMSAP3 →	+0.418	+0.823	<.001	<.001	3	6
PDAC	ITGA5 →	-0.476	-0.468	<.001	.009	3	6
GBM	C1QA →	-0.446	-0.528	.001	<.001	3	6
LSCC	C8orf82 →	+0.327	+0.540	.009	.006	3	5
GBM	DBI →	+0.491	+0.876	<.001	<.001	3	5
CCRCC	LOXL2 →	-0.702	-0.734	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016098 vs CAMSAP3 — PDAC

Explore this scatter interactively →