Monoterpenoid metabolic process

Across TCGA patient cohorts, RNA activity of the Monoterpenoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX7, CACNA1I, and SGSM3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoterpenoid metabolic process activity versus CBX7 in PDAC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CBX7 →	+0.902	+0.292	.002	.003	3	1
PDAC	CACNA1I →	+0.335	+0.270	<.001	.002	3	1
PDAC	SGSM3 →	+0.552	+0.310	<.001	<.001	3	1
PDAC	CHADL →	+0.728	+0.203	<.001	.006	3	1
PDAC	ISM2 →	-0.104	-0.207	<.001	.003	3	1
PDAC	E2F1 →	-1.422	-0.304	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016098 vs CBX7 — PDAC

Explore this scatter interactively →