Polyprenol metabolic process

Across TCGA cell cohorts, RNA activity of the Polyprenol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXNL2, HIGD2A, and HARS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NXNL2 grouped by Polyprenol metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NXNL2 →	+0.053	+0.333	<.001	.005	3	4
LUNG_NSCLC_LUSC	HIGD2A →	-1.072	-0.407	.006	.002	3	3
LUNG_NSCLC_LUSC	HARS1 →	-0.828	-0.344	.005	.002	3	3
LUNG_NSCLC_LUSC	SHLD3 →	-0.547	-0.279	<.001	<.001	3	3
BLOOD_Lymphoma	TMEM115 →	+1.313	+0.333	<.001	.005	3	3
BLOOD_Lymphoma	CTRL →	+1.590	+0.333	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NXNL2 by Polyprenol metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →