Polyprenol metabolic process

Across TCGA cell cohorts, RNA activity of the Polyprenol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C3, AKR1C2, and AKR1C1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyprenol metabolic process activity versus AKR1C3 in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AKR1C3 →	+5.568	+0.306	<.001	<.001	3	16
OESOPHAGUS	AKR1C2 →	+6.882	+0.395	<.001	<.001	3	12
LUNG_NSCLC_LUSC	AKR1C1 →	+8.064	+0.355	<.001	<.001	3	11
LIVER	AKR1B10 →	+7.944	+0.320	<.001	<.001	3	10
KIDNEY	OSGIN1 →	+2.524	+0.344	<.001	<.001	3	9
LIVER	AKR1B15 →	+2.972	+0.373	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016093 vs AKR1C3 — LIVER

Explore this scatter interactively →